Overnight urinary cortisol release in women with borderline personality disorder depends on comorbid PTSD and depressive psychopathology

Eur Psychiatry. 2007 Jul;22(5):309-12. doi: 10.1016/j.eurpsy.2006.09.002. Epub 2006 Dec 1.

Abstract

Free cortisol was investigated in BPD patients and healthy controls. A positive association was found between cortisol and depression scores, while the number of PTSD symptoms was negatively correlated with cortisol release. These findings suggest that alterations in cortisol release in BPD are strongly associated with the severity of psychopathology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Borderline Personality Disorder / diagnosis
  • Borderline Personality Disorder / psychology
  • Borderline Personality Disorder / urine*
  • Child
  • Child Abuse / psychology
  • Circadian Rhythm / physiology*
  • Comorbidity
  • Depressive Disorder / diagnosis
  • Depressive Disorder / psychology
  • Depressive Disorder / urine*
  • Female
  • Humans
  • Hydrocortisone / urine*
  • Life Change Events
  • Personality Assessment
  • Personality Inventory
  • Psychopathology
  • Statistics as Topic
  • Stress Disorders, Post-Traumatic / diagnosis
  • Stress Disorders, Post-Traumatic / psychology
  • Stress Disorders, Post-Traumatic / urine*

Substances

  • Hydrocortisone