Proximal effects of Toll-like receptor activation in dendritic cells

Curr Opin Immunol. 2007 Feb;19(1):73-8. doi: 10.1016/j.coi.2006.11.014. Epub 2006 Dec 4.

Abstract

Toll-like receptor (TLR) signals induce dendritic cell (DC) differentiation and influence the immunological outcome of their interactions with T cells. Recent in vitro studies demonstrate that TLR signals also trigger striking reorganisation of the DC vacuolar compartments, the cytoskeleton and the machinery of protein translation and turnover. Moreover, TLR ligation within endosomes and phagosomes appears to establish organelle autonomous signals. These changes, which mostly occur within minutes to a few hours after TLR engagement, are adaptations relevant to the antigen capture, processing and migratory phases of the DC life history.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism*
  • Humans
  • Signal Transduction / immunology
  • Toll-Like Receptors / metabolism*
  • Toll-Like Receptors / physiology

Substances

  • Toll-Like Receptors