Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

Chem Commun (Camb). 2006 Dec 28:(48):5009-11. doi: 10.1039/b613073a. Epub 2006 Nov 9.

Abstract

The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal-cocrystal reactions.

MeSH terms

  • Caffeine / chemistry*
  • Crystallization / methods
  • Crystallography, X-Ray
  • Hydrogen Bonding
  • Methane / analogs & derivatives
  • Methane / chemistry
  • Models, Molecular
  • Molecular Structure
  • Nitroparaffins / chemistry
  • Stereoisomerism
  • Tartrates / chemistry*
  • Theophylline / chemistry*

Substances

  • Nitroparaffins
  • Tartrates
  • Caffeine
  • Theophylline
  • Methane
  • nitromethane
  • tartaric acid