Abstract
4'',6''-Unsaturated cyclic ADP-carbocyclic-ribose (3) was designed as a novel stale mimic of cyclic ADP-ribose, an intracellular Ca2+-mobilizing second messenger, based on the previous SAR studies, and was successfully synthesized.
MeSH terms
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Animals
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Calcium / metabolism*
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Cells, Cultured
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Cyclic ADP-Ribose / analogs & derivatives*
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Cyclic ADP-Ribose / chemical synthesis
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Cyclic ADP-Ribose / chemistry
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Cyclic ADP-Ribose / pharmacology
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Humans
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Mice
Substances
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cyclic ADP-carbocyclic-ribose
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Cyclic ADP-Ribose
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Calcium