Synthesis and biological activity of 4'',6''-unsaturated cyclic ADP-carbocyclic-ribose

Nucleic Acids Symp Ser (Oxf). 2005:(49):25-6. doi: 10.1093/nass/49.1.25.

Abstract

4'',6''-Unsaturated cyclic ADP-carbocyclic-ribose (3) was designed as a novel stale mimic of cyclic ADP-ribose, an intracellular Ca2+-mobilizing second messenger, based on the previous SAR studies, and was successfully synthesized.

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Cells, Cultured
  • Cyclic ADP-Ribose / analogs & derivatives*
  • Cyclic ADP-Ribose / chemical synthesis
  • Cyclic ADP-Ribose / chemistry
  • Cyclic ADP-Ribose / pharmacology
  • Humans
  • Mice

Substances

  • cyclic ADP-carbocyclic-ribose
  • Cyclic ADP-Ribose
  • Calcium