Synthesis and properties of acridone-labeled base-discriminating fluorescent (BDF) nucleosides

Nucleic Acids Symp Ser (Oxf). 2006:(50):181-2. doi: 10.1093/nass/nrl090.

Abstract

We have developed novel acridone-labelled BDF probe which showed its potential in recognizing opposite matched base from its target sequence via enhancement of fiuorescence intensity. This probe emit at a longer wavelength than previously reported pyrene-labelled BDF probe and thus can be used in DNA chip.

MeSH terms

  • Acridines / chemistry*
  • Acridones
  • Base Pair Mismatch
  • Fluorescent Dyes / chemistry*
  • Nucleosides / chemical synthesis
  • Nucleosides / chemistry
  • Oligonucleotide Array Sequence Analysis
  • Oligonucleotide Probes / chemical synthesis*
  • Oligonucleotide Probes / chemistry
  • Spectrometry, Fluorescence

Substances

  • Acridines
  • Acridones
  • Fluorescent Dyes
  • Nucleosides
  • Oligonucleotide Probes
  • acridone