High levels of LDL-cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice

J Thromb Haemost. 2007 Mar;5(3):624-6. doi: 10.1111/j.1538-7836.2007.02358.x. Epub 2006 Dec 7.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Afibrinogenemia / blood*
  • Afibrinogenemia / genetics
  • Animals
  • Animals, Newborn
  • Apolipoproteins B / deficiency
  • Apolipoproteins B / genetics
  • Cholesterol / biosynthesis
  • Cholesterol, LDL / blood*
  • Female
  • Fetal Blood / metabolism
  • Fibrinogen / genetics
  • Fibrinogen / metabolism
  • Genotype
  • Hemorrhage / blood
  • Hemorrhage / genetics
  • Hybridization, Genetic
  • Male
  • Maternal-Fetal Exchange
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • P-Selectin / blood
  • Platelet Activation
  • Pregnancy
  • Pregnancy Complications, Hematologic / blood*
  • Pregnancy Complications, Hematologic / genetics
  • Receptors, LDL / deficiency
  • Receptors, LDL / genetics
  • Umbilicus / blood supply

Substances

  • Apolipoproteins B
  • Cholesterol, LDL
  • P-Selectin
  • Receptors, LDL
  • Fibrinogen
  • Cholesterol