[Nefopam by continuous intravenous injection and adverse drug reactions: which causality assessment?]

M Ould-Ahmed; I Drouillard; A El-Kartouti; P-F Wey; C Lions; J-Y Martinez

doi:10.1016/j.annfar.2006.07.080

[Nefopam by continuous intravenous injection and adverse drug reactions: which causality assessment?]

Ann Fr Anesth Reanim. 2007 Jan;26(1):74-6. doi: 10.1016/j.annfar.2006.07.080. Epub 2006 Dec 8.

[Article in French]

Authors

M Ould-Ahmed¹, I Drouillard, A El-Kartouti, P-F Wey, C Lions, J-Y Martinez

Affiliation

¹ Département d'anesthésie-réanimation-urgences, HIA Desgenettes, 108, boulevard Pinel, BP 25, 69998 Lyon, France. [email protected] <[email protected]>

PMID: 17158020
DOI: 10.1016/j.annfar.2006.07.080

Abstract

We report the case of a 77-year-old man, with nefopam postoperative analgesia, who developed subacute neurological symptoms, whereas he had profound hypoprotidemia and acute renal failure. Chronological, semiological and bibliographical criteria are in favour of causality assessment. The plasma nefopam concentration (135 ng/ml) during the neurological symptoms is another argument.

Publication types

Case Reports
English Abstract

MeSH terms

Acute Kidney Injury / chemically induced
Aged
Analgesics, Non-Narcotic / administration & dosage*
Analgesics, Non-Narcotic / adverse effects*
Humans
Hypoproteinemia / chemically induced
Injections, Intravenous
Male
Nefopam / administration & dosage*
Nefopam / adverse effects*
Pain, Postoperative / drug therapy

Substances

Analgesics, Non-Narcotic
Nefopam