First attempts at prediction of DNA strand-break yields using nanodosimetric data

G Garty; R Schulte; S Shchemelinin; B Grosswendt; C Leloup; G Assaf; A Breskin; R Chechik; V Bashkirov

doi:10.1093/rpd/ncl515

First attempts at prediction of DNA strand-break yields using nanodosimetric data

Radiat Prot Dosimetry. 2006;122(1-4):451-4. doi: 10.1093/rpd/ncl515. Epub 2006 Dec 8.

Authors

G Garty¹, R Schulte, S Shchemelinin, B Grosswendt, C Leloup, G Assaf, A Breskin, R Chechik, V Bashkirov

Affiliation

¹ Department of Particle Physics, Weizmann Institute of Science, Rehovot, Israel. [email protected]

PMID: 17158786
DOI: 10.1093/rpd/ncl515

Abstract

We present the first results of our attempts to correlate yields of ionisation clusters in a gas model of DNA and corresponding double-strand break (DSB) yields in irradiated plasmids, using a simple statistical model of DNA lesion formation. Based on the same statistical model, we also provide a comparison of simulated nanodosimetric data for electrons and published DSB yields obtained with the PARTRAC code.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Algorithms
Computer Simulation
DNA / chemistry*
DNA / radiation effects*
DNA Damage*
Databases, Factual
Dose-Response Relationship, Radiation
Microchemistry / methods
Models, Chemical*
Models, Genetic*
Nanotechnology / methods*
Pilot Projects
Radiation Dosage
Radiometry / methods*

Substances

DNA