Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Christel Rousseaux; Xavier Thuru; Agathe Gelot; Nicolas Barnich; Christel Neut; Laurent Dubuquoy; Caroline Dubuquoy; Emilie Merour; Karen Geboes; Mathias Chamaillard; Arthur Ouwehand; Greg Leyer; Didier Carcano; Jean-Frédéric Colombel; Denis Ardid; Pierre Desreumaux

doi:10.1038/nm1521

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Nat Med. 2007 Jan;13(1):35-7. doi: 10.1038/nm1521. Epub 2006 Dec 10.

Authors

Christel Rousseaux¹, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut, Laurent Dubuquoy, Caroline Dubuquoy, Emilie Merour, Karen Geboes, Mathias Chamaillard, Arthur Ouwehand, Greg Leyer, Didier Carcano, Jean-Frédéric Colombel, Denis Ardid, Pierre Desreumaux

Affiliation

¹ Institut National de la Santé et de la Recherche Médicale (INSERM) U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France.

PMID: 17159985
DOI: 10.1038/nm1521

Abstract

Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treatment of abdominal pain and irritable bowel syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abdominal Pain / physiopathology*
Abdominal Pain / prevention & control
Administration, Oral
Analgesics, Opioid / administration & dosage
Analgesics, Opioid / pharmacology
Animals
Cannabinoid Receptor Antagonists
Colon / drug effects
Colon / microbiology
Colon / physiopathology
Dose-Response Relationship, Drug
HT29 Cells
Humans
Indoles / administration & dosage
Indoles / pharmacology
Intestines / drug effects
Intestines / microbiology
Intestines / physiopathology*
Lactobacillus acidophilus / physiology*
Male
Mice
Mice, Inbred BALB C
Morphine / administration & dosage
Morphine / pharmacology
Naloxone / administration & dosage
Naloxone / pharmacology
Narcotic Antagonists / administration & dosage
Narcotic Antagonists / pharmacology
Probiotics / administration & dosage
Probiotics / pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB2 / antagonists & inhibitors
Receptor, Cannabinoid, CB2 / biosynthesis
Receptor, Cannabinoid, CB2 / physiology
Receptors, Cannabinoid / biosynthesis
Receptors, Cannabinoid / physiology*
Receptors, Opioid / biosynthesis
Receptors, Opioid / physiology*
Receptors, Opioid, mu / antagonists & inhibitors
Receptors, Opioid, mu / biosynthesis
Receptors, Opioid, mu / physiology
Rectum / drug effects
Rectum / microbiology
Rectum / physiopathology

Substances

Analgesics, Opioid
Cannabinoid Receptor Antagonists
Indoles
Narcotic Antagonists
Receptor, Cannabinoid, CB2
Receptors, Cannabinoid
Receptors, Opioid
Receptors, Opioid, mu
Naloxone
Morphine
iodopravadoline