Abstract
In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology*
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Cells, Cultured
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Hepacivirus / drug effects*
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Humans
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Purine Nucleosides / chemical synthesis
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Purine Nucleosides / chemistry*
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Purine Nucleosides / pharmacology*
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RNA, Viral / drug effects
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Structure-Activity Relationship
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Virus Replication / drug effects
Substances
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Antiviral Agents
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Purine Nucleosides
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RNA, Viral