Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators

Jasmina J Allen; Kevan M Shokat

doi:10.1021/cb600137r

Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators

ACS Chem Biol. 2006 Apr 25;1(3):139-40. doi: 10.1021/cb600137r.

Authors

Jasmina J Allen¹, Kevan M Shokat

Affiliation

¹ University of California-San Fransisco, 600 16th Street, GH-N512D, San Francisco, California 94143, USA.

PMID: 17163659
DOI: 10.1021/cb600137r

Abstract

A recent study analyzed the transcriptional effects induced by a panel of non-steroidal glucocorticoid receptor modulators. The authors discover patterns of cell-, gene-, and mechanism-specific regulation, with implications for development of improved anti-inflammatory agents.

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacokinetics*
Genomics*
Homeostasis
Ligands
Models, Biological
Receptors, Cytoplasmic and Nuclear / genetics
Receptors, Glucocorticoid / genetics*
Selective Estrogen Receptor Modulators / pharmacokinetics
Substrate Specificity
Transcription, Genetic*

Substances

Anti-Inflammatory Agents
Ligands
Receptors, Cytoplasmic and Nuclear
Receptors, Glucocorticoid
Selective Estrogen Receptor Modulators