Abstract
Although the critical factors necessary for IBD pathogenesis remain mysterious, interest in the potential role of defective epithelial barrier function continues to grow. New insight into the mechanisms responsible for barrier dysfunction in IBD may lead to understanding its contribution to disease development and progression.
Publication types
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Comment
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Membrane Permeability / physiology
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Colitis, Ulcerative / etiology
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Colitis, Ulcerative / physiopathology
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Crohn Disease / etiology
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Crohn Disease / physiopathology
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Epithelium / physiopathology
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Humans
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Inflammatory Bowel Diseases / etiology*
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Inflammatory Bowel Diseases / physiopathology
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Interferon-gamma / metabolism
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Intestinal Mucosa / physiopathology*
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Membrane Proteins / metabolism
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Models, Biological
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Myosin-Light-Chain Kinase / metabolism
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Tight Junctions / metabolism
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Membrane Proteins
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Tumor Necrosis Factor-alpha
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Interferon-gamma
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Myosin-Light-Chain Kinase