Abstract
The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described.
MeSH terms
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Caco-2 Cells
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Humans
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Indicators and Reagents
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Models, Molecular
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Molecular Conformation
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Piperazines / chemical synthesis*
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Piperazines / pharmacology
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Pyrazoles / chemical synthesis*
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Pyrazoles / pharmacology
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
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Radioligand Assay
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Receptor, Serotonin, 5-HT2C / drug effects
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Receptors, Somatostatin / antagonists & inhibitors*
Substances
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Indicators and Reagents
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MCHR1 protein, human
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Piperazines
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Pyrazoles
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Pyrroles
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Receptor, Serotonin, 5-HT2C
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Receptors, Somatostatin
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pyrazolopiperazinone
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pyrrolopiperazinone