Translocation (10;17)(p15;q21) is a recurrent anomaly in acute myeloblastic leukemia

Cancer Genet Cytogenet. 2007 Jan 1;172(1):74-6. doi: 10.1016/j.cancergencyto.2006.08.001.

Abstract

We report here two cases of patients with acute myeloblastic leukemia, type M1 (FAB classification), associated with a t(10;17)(p15;q21). Fluorescence in situ hybridization with the LSI PML/RARA dual-color probe showed the breakpoint to be distal to the RARA locus. Four other patients with this translocation have been reported, three of them having acute undifferentiated or poorly differentiated leukemia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chromosomes, Human, Pair 10 / genetics*
  • Chromosomes, Human, Pair 17 / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Neoplasm Proteins / genetics
  • Neoplasm Recurrence, Local / genetics
  • Nuclear Proteins / genetics
  • Promyelocytic Leukemia Protein
  • Receptors, Retinoic Acid / genetics
  • Retinoic Acid Receptor alpha
  • Transcription Factors / genetics
  • Translocation, Genetic / genetics*
  • Tumor Suppressor Proteins / genetics

Substances

  • Neoplasm Proteins
  • Nuclear Proteins
  • Promyelocytic Leukemia Protein
  • RARA protein, human
  • Receptors, Retinoic Acid
  • Retinoic Acid Receptor alpha
  • Transcription Factors
  • Tumor Suppressor Proteins
  • PML protein, human