Abstract
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetazolamide / pharmacology
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Animals
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Aquaporin 4 / antagonists & inhibitors*
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Arylsulfonic Acids / pharmacology*
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Biological Transport / drug effects
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Humans
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Inhibitory Concentration 50
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Oocytes
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Osmosis
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Phloretin / pharmacology
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Structure-Activity Relationship
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Sulfonamides / pharmacology*
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Transfection
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Water / metabolism
Substances
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Aquaporin 4
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Arylsulfonic Acids
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Sulfonamides
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Water
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Acetazolamide
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Phloretin