Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays?

J Cell Biol. 2006 Dec 18;175(6):849-51. doi: 10.1083/jcb.200611149.

Abstract

Two related enzymes, katanin and spastin, use the energy from ATP hydrolysis to sever microtubules. Two new studies (one in this issue; see McNally et al., p. 881) show that microtubule severing by katanin provides a means for increasing microtubule density in meiotic spindles. Interestingly, loss of spastin leads to a sparser microtubule array in axons and synaptic boutons. Together, these studies hint at a wider role for microtubule-severing enzymes in the formation and organization of noncentrosomal microtubule arrays by generating new seeds for microtubule growth.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Adenosine Triphosphatases / physiology*
  • Animals
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / embryology
  • Caenorhabditis elegans / enzymology*
  • Caenorhabditis elegans Proteins / physiology*
  • Embryo, Nonmammalian / cytology
  • Embryo, Nonmammalian / enzymology
  • Katanin
  • Meiosis / physiology*
  • Microtubule Proteins / physiology
  • Microtubules / metabolism*
  • Spindle Apparatus / metabolism

Substances

  • Caenorhabditis elegans Proteins
  • Microtubule Proteins
  • Adenosine Triphosphatases
  • Katanin