We describe an extremely rare case of an ileocolic intussusception with an appendiceal mucocele as the lead-point and cause of acute right lower quadrant pain in an adult patient. There are only few reported cases of this entity in the radiologic literature. We describe the multislice (computed tomography) CT features and emphasize the value of multiplanar reformations. We also discuss how specific findings on CT should allow for a correct preoperative diagnosis.