Abstract
We report on the nuclear receptor binding affinities, cellular activities of transrepression and transactivation, and anti-inflammatory properties of a quinol-4-one and other A-ring mimetic containing nonsteroidal class of glucocorticoid agonists.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Aromatase / metabolism
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Dexamethasone / pharmacology
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Female
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Glucocorticoids / agonists*
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HeLa Cells
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Humans
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Lipopolysaccharides / pharmacology
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Mice
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Mice, Inbred BALB C
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Molecular Mimicry*
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Quinolones / chemical synthesis
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Quinolones / chemistry
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Quinolones / pharmacology*
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Trans-Activators / chemical synthesis
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Trans-Activators / chemistry
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Trans-Activators / pharmacology*
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Transcriptional Activation
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Glucocorticoids
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Lipopolysaccharides
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Quinolones
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Receptors, Cytoplasmic and Nuclear
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Trans-Activators
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Dexamethasone
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Aromatase