Functional imaging before and after constraint-induced language therapy for aphasia using magnetoencephalography

Joshua I Breier; Lynn M Maher; Barbra Novak; Andrew C Papanicolaou

doi:10.1080/13554790601126054

Functional imaging before and after constraint-induced language therapy for aphasia using magnetoencephalography

Neurocase. 2006 Dec;12(6):322-31. doi: 10.1080/13554790601126054.

Authors

Joshua I Breier¹, Lynn M Maher, Barbra Novak, Andrew C Papanicolaou

Affiliation

¹ Division of Clinical Neurosciences in the Department of Neurosurgery, University of Texas - Houston Health Science Center, Houston, Texas 77030, USA. [email protected]

PMID: 17182395
DOI: 10.1080/13554790601126054

Abstract

Five patients with chronic aphasia underwent functional imaging using magnetoencephalography (MEG) before and after constraint-induced language therapy (CILT). Patients who responded well to CILT exhibited a greater degree of late MEG activation in posterior language areas of the left hemisphere and homotopic areas of the right hemisphere prior to therapy than those who did not respond well. Response to CILT, however, was positively correlated with the degree of pre-therapy MEG activity within posterior areas of the right hemisphere only on an individual basis.

Publication types

Clinical Trial

MeSH terms

Aged
Aphasia / diagnosis*
Aphasia / physiopathology
Aphasia / therapy*
Brain Mapping / methods
Causality
Cerebral Cortex / anatomy & histology
Cerebral Cortex / physiopathology*
Educational Status
Female
Functional Laterality / physiology*
Humans
Language
Language Tests
Language Therapy / methods*
Language Therapy / trends
Magnetic Resonance Imaging
Magnetoencephalography / methods*
Magnetoencephalography / trends
Male
Middle Aged
Predictive Value of Tests
Reaction Time / physiology
Recovery of Function / physiology
Treatment Outcome
Verbal Behavior / physiology