Abstract
The interaction of ketamine with the 5-HT3 receptor of rabbit nodose ganglion neurones is described. Ketamine (3-30 microM) enhanced 5-HT3 receptor-mediated currents recorded under voltage-clamp conditions. This action did not appear to be related to the known effect of ketamine of inhibiting 5-HT uptake.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Evoked Potentials / drug effects
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In Vitro Techniques
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Ion Channels / drug effects
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Ion Channels / metabolism*
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Ketamine / pharmacology*
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Neurons / drug effects
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Neurons / metabolism*
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Nodose Ganglion / cytology*
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Nodose Ganglion / drug effects
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Nodose Ganglion / metabolism
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Rabbits
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / physiology*
Substances
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Ion Channels
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Receptors, Serotonin
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Ketamine