Abstract
The absolute configuration of the two stereocenters of (+)-sporotricale (2a), a bioactive phthalide secondary metabolite, was determined through circular dichroism and by applying Mosher's method. The structure of 6-hydroxysporotricale (2c), isolated from cultures in vitro of Sporotrichum laxum, was also elucidated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Benzofurans / chemistry*
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Benzofurans / isolation & purification
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Benzofurans / pharmacology
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Chickens
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Chorioallantoic Membrane / drug effects
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Drug Screening Assays, Antitumor
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Endothelial Cells / drug effects
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Fibroblast Growth Factors / drug effects
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Molecular Structure
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Neovascularization, Physiologic / drug effects
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Sporothrix / chemistry*
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Stereoisomerism
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Zygote / drug effects
Substances
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6-hydroxysporotricale
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Antineoplastic Agents
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Benzofurans
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sporotricale
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Fibroblast Growth Factors