Abstract
In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H+-ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1-8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D- and 2D-NMR spectroscopy, and MS spectrometry. One of these compounds, 8, a regioisomer of chlorohydrin destruxin E (7), is a new destruxin.
MeSH terms
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Animals
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Chickens
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Depsipeptides / metabolism*
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Depsipeptides / pharmacology*
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Dose-Response Relationship, Drug
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Fermentation
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Inhibitory Concentration 50
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Metarhizium / metabolism
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Molecular Structure
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Osteoclasts
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Saccharomyces cerevisiae / enzymology*
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Time Factors
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Vacuolar Proton-Translocating ATPases / antagonists & inhibitors*
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Vacuolar Proton-Translocating ATPases / metabolism
Substances
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Depsipeptides
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Vacuolar Proton-Translocating ATPases