Interactions of antiretroviral drugs with anti-infectives and other antiretrovirals

Combination antiretroviral (ARV) treatment is a potent and effective therapy for human immunodeficiency virus infection. Unfortunately, ARV drugs frequently interact among themselves, as well as with other anti-infectives. These interactions determine positive or negative consequences resulting in recommendations to avoid some combinations or to adjust the dosage of coadministered drugs. The effective clinical use of ARVs requires deep knowledge of interaction mechanisms and the consequent recommendations when coadministering interacting ARVs with other anti-infectives. A brief review of the present knowledge on interactions of ARVs with anti-infective drugs is presented.