Abstract
Rare cases of acute promyelocytic leukemia (APL) are associated with a t(11;17) translocation and a PLZF-RARalpha fusion transcript. Because of molecular specificities of the fusion protein, ATRA efficiency is often reduced in these cases. We present herein the case of an 83-year old patient which has been successfully treated by ATRA and Daunorubicin. The described quantitative RT-PCR method allowed successful monitoring and confirmation of the molecular response.
MeSH terms
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Aged, 80 and over
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics
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Bone Marrow / chemistry
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Bone Marrow / pathology
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Chromosomes, Human, Pair 15 / genetics
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Chromosomes, Human, Pair 15 / ultrastructure
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Chromosomes, Human, Pair 17 / genetics
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Chromosomes, Human, Pair 17 / ultrastructure
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Computer Systems
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Daunorubicin / administration & dosage
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Humans
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Leukemia, Promyelocytic, Acute / drug therapy
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Leukemia, Promyelocytic, Acute / genetics*
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Mercaptopurine / administration & dosage
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Methotrexate / administration & dosage
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Neoplasm Proteins / analysis
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Neoplasm Proteins / genetics*
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Oncogene Proteins, Fusion / analysis
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Oncogene Proteins, Fusion / genetics*
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Remission Induction
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Reverse Transcriptase Polymerase Chain Reaction
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Translocation, Genetic
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Tretinoin / administration & dosage
Substances
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Biomarkers, Tumor
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Neoplasm Proteins
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Oncogene Proteins, Fusion
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PLZF-RARalpha fusion protein, human
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Tretinoin
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Mercaptopurine
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Methotrexate
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Daunorubicin