Although vertebral fractures in fused spinal segments have been reported, we are not aware of any descriptions of vertebral body compression fractures in solidly fused and instrumented segments. We report a patient who sustained a vertebral-body compression fracture of the L1 vertebra in an instrumented and fused spinal segment from T10 to L5. The fracture occurred during self-insertion of a rectal suppository. No intervention was required to treat the fracture, and there was no long-term clinical effect.