Abstract
This study investigated the genetic bases of attenuation in the Bacillus anthracis vaccine strain "Carbosap" used in Italy against anthrax in cattle and sheep. Twelve genes involved in virulence regulatory pathways underwent sequence analysis in comparison with a B. anthracis virulent strain.
MeSH terms
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Animals
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Anthrax / microbiology
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Anthrax / prevention & control
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Anthrax / veterinary
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Anthrax Vaccines*
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Bacillus anthracis / classification
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Bacillus anthracis / genetics
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Bacillus anthracis / immunology
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Bacillus anthracis / pathogenicity*
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Bacterial Proteins / genetics*
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Cattle
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Gene Expression Regulation, Bacterial
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Italy
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Polymerase Chain Reaction / methods
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Sequence Analysis, DNA
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Sheep
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Vaccines, Attenuated*
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Virulence
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Virulence Factors / genetics*
Substances
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Anthrax Vaccines
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Bacterial Proteins
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Vaccines, Attenuated
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Virulence Factors