IAPP mimic blocks Abeta cytotoxic self-assembly: cross-suppression of amyloid toxicity of Abeta and IAPP suggests a molecular link between Alzheimer's disease and type II diabetes

Angew Chem Int Ed Engl. 2007;46(8):1246-52. doi: 10.1002/anie.200604056.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amino Acid Sequence
  • Amyloid / chemistry*
  • Amyloid beta-Peptides / chemistry*
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Peptides / toxicity*
  • Amyloid beta-Peptides / ultrastructure
  • Animals
  • Biomimetic Materials / chemistry*
  • Biomimetic Materials / metabolism
  • Biomimetic Materials / pharmacology*
  • Cell Survival / drug effects
  • Diabetes Mellitus, Type 2 / metabolism*
  • Islet Amyloid Polypeptide
  • Microscopy, Electron, Transmission
  • Molecular Sequence Data
  • PC12 Cells
  • Protein Precursors / chemistry*
  • Rats

Substances

  • Amyloid
  • Amyloid beta-Peptides
  • Islet Amyloid Polypeptide
  • Protein Precursors