Abstract
The function of SpanX proteins is unknown, evidence is accumulating to suggest their involvement in tumorigenesis. A locus in Xq27, where the SpanX gene family is located, has been associated with testicular germ cell tumor (TGCT) onset. Therefore, we evaluated the presence of SpanX mRNA in six TGCT cases by RT-PCR. The results showed that SpanX mRNA is present in TGCT, confirming transcriptional activity of these genes in such tumors.
MeSH terms
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Base Sequence
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Chromosomes, Human, X / genetics
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DNA, Complementary / genetics
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Gene Expression Regulation, Neoplastic*
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Humans
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Male
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Molecular Sequence Data
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Neoplasms, Germ Cell and Embryonal / genetics*
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Nuclear Proteins / genetics*
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RNA, Messenger / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Alignment
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Testicular Neoplasms / genetics*
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Transcription, Genetic
Substances
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DNA, Complementary
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Nuclear Proteins
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RNA, Messenger
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SPANXA1 protein, human