An efficient and chemoselective synthesis of N-substituted 2-aminopyridines via a microwave-assisted multicomponent reaction

Org Biomol Chem. 2007 Jan 21;5(2):355-9. doi: 10.1039/b614747j. Epub 2006 Dec 4.

Abstract

A facile and selective synthesis of N-substituted 2-aminopyridines is accomplished via microwave-assisted multi-component reactions controlled by the basicity of amine and the nature of solvent. In addition, a possible mechanism accounting for the reaction was proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Aminopyridines / chemical synthesis*
  • Aminopyridines / chemistry*
  • Chemistry, Organic / methods
  • Combinatorial Chemistry Techniques
  • Heating
  • Microwaves
  • Models, Chemical
  • Molecular Structure
  • Solvents / chemistry
  • Spectrophotometry, Infrared
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Amines
  • Aminopyridines
  • Solvents