Abstract
We investigated the functional role of the Leishmania histone H1 and demonstrate for the first time that addition of histone H1 has a strong effect on microccocal digestion, chromatin condensation of parasite nuclei and that its overexpression can modulate parasite infectivity in vivo.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Chromatin / metabolism*
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Gene Expression
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Histones / genetics
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Histones / physiology*
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Leishmania major / chemistry
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Leishmania major / pathogenicity
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Leishmania major / physiology*
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Leishmaniasis, Cutaneous / parasitology*
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Macrophages / parasitology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Signal Transduction
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Transfection
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Virulence