Hepatic veno-occlusive disease after neoadjuvant treatment of colorectal liver metastases with oxaliplatin: a lesson of the month

A P Schouten van der Velden; C J A Punt; J H J Van Krieken; V A Derleyn; T J M Ruers

doi:10.1016/j.ejso.2006.11.022

Hepatic veno-occlusive disease after neoadjuvant treatment of colorectal liver metastases with oxaliplatin: a lesson of the month

Eur J Surg Oncol. 2008 Mar;34(3):353-5. doi: 10.1016/j.ejso.2006.11.022. Epub 2007 Jan 5.

Authors

A P Schouten van der Velden¹, C J A Punt, J H J Van Krieken, V A Derleyn, T J M Ruers

Affiliation

¹ Department of Surgery, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

PMID: 17207961
DOI: 10.1016/j.ejso.2006.11.022

Abstract

A patient is presented who was treated with neoadjuvant oxaliplatin-based chemotherapy followed by hepatic resection complicated by fatal liver failure. Histopathological examination revealed hepatic veno-occlusive disease, which is an infrequent reported side effect of oxaliplatin.

Publication types

Case Reports

MeSH terms

Antineoplastic Agents / adverse effects*
Colorectal Neoplasms / pathology
Fatal Outcome
Female
Hepatectomy
Hepatic Veno-Occlusive Disease / chemically induced*
Hepatic Veno-Occlusive Disease / pathology
Humans
Liver Neoplasms / drug therapy*
Liver Neoplasms / secondary
Liver Neoplasms / surgery
Male
Middle Aged
Multiple Organ Failure / chemically induced
Neoadjuvant Therapy / adverse effects*
Organoplatinum Compounds / adverse effects*
Oxaliplatin
Postoperative Complications / chemically induced
Postoperative Complications / pathology

Substances

Antineoplastic Agents
Organoplatinum Compounds
Oxaliplatin