Abstract
In this study, we sought to elucidate whether phenylpropanolamine (PPA) in cold remedies (small and divided doses) increases the risk of hemorrhagic stroke (HS). PPA exposure significantly increased the risk, and the risk was much higher in women. In women, linear trends were also found in recency, duration, and dosage of PPA exposure. PPA contained in cold remedies increases the risk of HS, particularly in women.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Case-Control Studies
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Common Cold / drug therapy
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Common Cold / epidemiology
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Comorbidity
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Double-Blind Method
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Female
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Humans
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Incidence
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Intracranial Hemorrhages / epidemiology*
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Korea / epidemiology
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Male
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Middle Aged
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Nasal Decongestants / therapeutic use
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Nonprescription Drugs / therapeutic use
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Phenylpropanolamine / therapeutic use*
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Risk Assessment / methods*
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Risk Factors
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Stroke / epidemiology*
Substances
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Nasal Decongestants
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Nonprescription Drugs
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Phenylpropanolamine