Abstract
Enzyme immunoassay and immunoprecipitation test of viral proteins, by applying a tick-borne encephalitis (TBE) viral protein E monoclonal antibody kit, have shown that TBE adaptation to ticks and mammals may cause a considerable change in the antigenic structure of surface glycoprotein E, by involving different antigenic domains, including a neutralizing epitope that seems to participate at the early stages of interaction of virions with the cell membrane.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological
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Animals
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Antibodies, Monoclonal / immunology
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Antibodies, Viral / immunology
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Antigens, Viral / immunology*
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Encephalitis Viruses, Tick-Borne / immunology
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Encephalitis Viruses, Tick-Borne / physiology*
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Epitopes / immunology
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Mammals*
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Neutralization Tests
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Serial Passage
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Ticks*
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Viral Envelope Proteins / immunology*
Substances
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Antibodies, Monoclonal
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Antibodies, Viral
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Antigens, Viral
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Epitopes
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Viral Envelope Proteins
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glycoprotein E, Flavivirus