Nociception and TRP channels

Handb Exp Pharmacol. 2007:(179):489-505. doi: 10.1007/978-3-540-34891-7_29.

Abstract

Pain is initiated when noxious stimuli excite the peripheral terminals of specialized primary afferent neurons called nociceptors. Many molecules are involved in conversion of the noxious stimuli to the electrical signals in the nociceptor endings. Among them, TRP channels play important roles in detecting noxious stimuli.

Publication types

  • Review

MeSH terms

  • Analgesics / pharmacology
  • Animals
  • Humans
  • Inflammation / complications
  • Inflammation / physiopathology
  • Nociceptors / drug effects
  • Nociceptors / physiology*
  • Pain / drug therapy
  • Pain / etiology
  • Pain / physiopathology*
  • Transient Receptor Potential Channels / drug effects
  • Transient Receptor Potential Channels / physiology*

Substances

  • Analgesics
  • Transient Receptor Potential Channels