Pulmonary blastoma with germ cell (yolk sac) differentiation: report of two cases

Mod Pathol. 1991 Sep;4(5):566-70.

Abstract

Pulmonary blastoma is a rare lung neoplasm of disputed histogenesis and variable biologic behavior. Typical cases contain both epithelial and mesenchymal tissues, and a variety of patterns of differentiation have been described. While expression of oncofetal antigens in these tumors has been noted rarely, a coexisting component of germ cell tumor has not been reported previously. We describe the clinical and pathologic features of two cases of pulmonary blastoma having alpha-fetoprotein production and histologic areas of yolk sac tumor. We also report the finding of immunohistochemical staining of fetal lung tissue for alpha-fetoprotein.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cell Transformation, Neoplastic / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Lung / chemistry
  • Lung / embryology
  • Lung / pathology
  • Lung Neoplasms / chemistry
  • Lung Neoplasms / pathology*
  • Mesonephroma / chemistry
  • Mesonephroma / pathology*
  • Teratoma / chemistry
  • Teratoma / pathology*
  • alpha-Fetoproteins / analysis

Substances

  • alpha-Fetoproteins