New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin

Chem Commun (Camb). 2007 Jan 28:(4):359-61. doi: 10.1039/b614678c. Epub 2006 Nov 23.

Abstract

Hydroxyethylphosphonate is a required intermediate in fosfomycin biosynthesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fosfomycin / biosynthesis*
  • Fosfomycin / chemistry*
  • Methylation
  • Methyltransferases / metabolism
  • Molecular Structure
  • Organophosphonates / chemistry
  • Streptomyces lividans / chemistry
  • Streptomyces lividans / genetics
  • Streptomyces lividans / metabolism

Substances

  • 2-hydroxyethyl phosphonate
  • Organophosphonates
  • Fosfomycin
  • Methyltransferases