Abstract
The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Flow Cytometry
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Humans
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Jurkat Cells
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Metals / pharmacology*
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Microscopy, Fluorescence / methods*
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Models, Molecular
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Molecular Structure
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Protein Binding / drug effects
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Receptors, CXCR4 / antagonists & inhibitors*
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Receptors, CXCR4 / chemistry
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Receptors, CXCR4 / metabolism*