Synthesis and antigenotoxic activity of some naphtho[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives

Fakher Chabchoub; Mehdi Messaâd; Hédi Ben Mansour; Leila Chekir-Ghedira; Mansour Salem

doi:10.1016/j.ejmech.2006.12.002

Synthesis and antigenotoxic activity of some naphtho[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives

Eur J Med Chem. 2007 May;42(5):715-8. doi: 10.1016/j.ejmech.2006.12.002. Epub 2006 Dec 15.

Authors

Fakher Chabchoub¹, Mehdi Messaâd, Hédi Ben Mansour, Leila Chekir-Ghedira, Mansour Salem

Affiliation

¹ Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Sfax, Tunisia.

PMID: 17224204
DOI: 10.1016/j.ejmech.2006.12.002

Abstract

In this study, some pyranotriazolopyrimidine derivatives were synthesised by reacting ethoxymethyleneamino derivatives with hydrazides. Their structures were elucidated by IR, (1)H NMR, and (13)C NMR spectroscopic data and elemental analyses. Antigenotoxic activity of the obtained compounds was tested in Escherichia coli PQ37 by using the SOS chromotest.

MeSH terms

Antimutagenic Agents / chemical synthesis*
Antimutagenic Agents / pharmacology*
Escherichia coli / drug effects
Magnetic Resonance Spectroscopy
Pyrimidines / chemical synthesis*
Pyrimidines / pharmacology*
Spectrophotometry, Infrared

Substances

Antimutagenic Agents
Pyrimidines