Analysis of anti-protective antigen IgG subclass distribution in recipients of anthrax vaccine adsorbed (AVA) and patients with cutaneous and inhalation anthrax

V A Semenova; D S Schmidt; T H Taylor Jr; H Li; E Steward-Clark; S D Soroka; M M Ballard; C P Quinn

doi:10.1016/j.vaccine.2006.11.028

Analysis of anti-protective antigen IgG subclass distribution in recipients of anthrax vaccine adsorbed (AVA) and patients with cutaneous and inhalation anthrax

Vaccine. 2007 Feb 26;25(10):1780-8. doi: 10.1016/j.vaccine.2006.11.028. Epub 2006 Nov 27.

Authors

V A Semenova¹, D S Schmidt, T H Taylor Jr, H Li, E Steward-Clark, S D Soroka, M M Ballard, C P Quinn

Affiliation

¹ Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. [email protected]

PMID: 17229495
DOI: 10.1016/j.vaccine.2006.11.028

Abstract

The anti-PA IgG1, IgG2, IgG3, and IgG4 subclass responses to clinical anthrax and to different numbers of anthrax vaccine adsorbed (AVA, BioThrax) injections were determined in a cross-sectional study of sera from 63 vaccinees and 13 clinical anthrax patients. The data show that both vaccination with three AVA injections and clinical anthrax elicit anti-PA IgG1, IgG2, and IgG3 subclass responses. An anti-PA IgG4 response was detected in AVA recipients after the fourth injection. The anthrax lethal toxin (LTx) neutralization efficacy of sera from recipients who received 4 to > or =10 AVA injections did not vary significantly in relation to changes in distribution of anti-PA IgG1 and IgG4 subclasses.

Publication types

Comparative Study

MeSH terms

Adult
Aged
Anthrax / immunology*
Anthrax Vaccines / immunology*
Antibodies, Bacterial / blood*
Antibodies, Bacterial / classification*
Antigens, Bacterial / immunology*
Antitoxins / blood
Bacterial Toxins / immunology*
Female
Humans
Immunoglobulin G / blood*
Immunoglobulin G / classification*
Male
Middle Aged

Substances

Anthrax Vaccines
Antibodies, Bacterial
Antigens, Bacterial
Antitoxins
Bacterial Toxins
Immunoglobulin G
anthrax toxin