Abstract
The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Biomarkers, Tumor / metabolism
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Female
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Humans
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Mucin-4
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Mucins / metabolism*
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Neoplasm Metastasis
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Neoplasms / diagnosis
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Neoplasms / metabolism*
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Neoplasms / pathology
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Neoplasms / therapy
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Ovarian Neoplasms / diagnosis
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Ovarian Neoplasms / metabolism
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Ovarian Neoplasms / pathology
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Ovarian Neoplasms / therapy
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Pancreatic Neoplasms / diagnosis
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Pancreatic Neoplasms / metabolism
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Pancreatic Neoplasms / pathology
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Pancreatic Neoplasms / therapy
Substances
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Biomarkers, Tumor
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MUC4 protein, human
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Mucin-4
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Mucins