Abstract
Chromatin-associated protein HIM-17 was previously shown to function in the chromosomal events of meiotic prophase. Here we report an additional role for HIM-17 in regulating the balance between germ cell proliferation and meiotic development. A cryptic function for HIM-17 in promoting meiotic entry and/or inhibiting proliferation was revealed by defects in germline organization in him-17 mutants grown at high temperature (25 degrees) and by a synthetic tumorous germline phenotype in glp-1(ar202); him-17 mutants at 15 degrees.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Genetically Modified
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Caenorhabditis elegans / cytology*
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / physiology*
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / physiology*
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / physiology*
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Cell Proliferation
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Female
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Gene Silencing
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Genes, Helminth
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Germ-Line Mutation
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Male
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Meiosis / genetics
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Meiosis / physiology
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Mutation
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Neoplasms, Experimental / genetics
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Phenotype
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Reproduction / genetics
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Reproduction / physiology
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Temperature
Substances
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Caenorhabditis elegans Proteins
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Cell Cycle Proteins
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HIM-17 protein, C elegans