Abstract
How memory is retained is an immunological mystery. One possibility, argued here by Fons UytdeHaag and colleagues, is that memory is imprinted in the somatically-mutated Ig expressed by certain CD5+ B cells. The theory proposes that the Ig expressed by this self-renewing population acts as surrogate antigen, selecting and stimulating emerging antigen-specific lymphocytes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Anti-Idiotypic / genetics
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Antibodies, Anti-Idiotypic / immunology
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Antigens, CD*
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B-Lymphocyte Subsets / immunology*
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CD5 Antigens
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Gene Rearrangement, B-Lymphocyte*
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Genes, Immunoglobulin
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Hematopoietic Stem Cells / immunology
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Humans
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Immunoglobulin Heavy Chains / genetics
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Immunoglobulin Light Chains / genetics
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Immunoglobulin Variable Region / genetics
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Immunologic Memory*
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Mice
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Models, Biological
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Mutation
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Plasma Cells / immunology
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Receptors, Antigen, B-Cell / genetics
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Receptors, Antigen, B-Cell / immunology*
Substances
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Antibodies, Anti-Idiotypic
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Antigens, CD
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CD5 Antigens
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Immunoglobulin Heavy Chains
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Immunoglobulin Light Chains
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Immunoglobulin Variable Region
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Receptors, Antigen, B-Cell