Evaluation of the in vitro activity of daptomycin against 19615 clinical isolates of Gram-positive cocci collected in North American hospitals (2002-2005)

Michael A Pfaller; Helio S Sader; Ronald N Jones

doi:10.1016/j.diagmicrobio.2006.10.007

Evaluation of the in vitro activity of daptomycin against 19615 clinical isolates of Gram-positive cocci collected in North American hospitals (2002-2005)

Diagn Microbiol Infect Dis. 2007 Apr;57(4):459-65. doi: 10.1016/j.diagmicrobio.2006.10.007. Epub 2007 Jan 19.

Authors

Michael A Pfaller¹, Helio S Sader, Ronald N Jones

Affiliation

¹ University of Iowa, Iowa City, IA 52242, USA.

PMID: 17240105
DOI: 10.1016/j.diagmicrobio.2006.10.007

Abstract

We evaluated the antimicrobial activity of daptomycin against 19,615 clinical strains consecutively collected by numerous centers located across the United States and Canada (2002-2005). Daptomycin was very active against all indicated species (>99% susceptible), with the highest MIC results being 2, 8, 0.5, and 1 microg/mL for staphylococci, enterococci, beta-hemolytic streptococci, and viridans group streptococci, respectively, and no significant loss in potency was observed over the period studied.

Publication types

Evaluation Study

MeSH terms

Anti-Bacterial Agents / pharmacology*
Daptomycin / pharmacology*
Drug Resistance, Bacterial
Enterococcus faecalis / drug effects
Enterococcus faecalis / isolation & purification
Gram-Positive Bacterial Infections / microbiology
Gram-Positive Cocci / classification
Gram-Positive Cocci / drug effects*
Gram-Positive Cocci / isolation & purification
Hospitals*
Humans
Microbial Sensitivity Tests
North America
Staphylococcus aureus / drug effects
Staphylococcus aureus / isolation & purification
Streptococcus / drug effects
Streptococcus / isolation & purification

Substances

Anti-Bacterial Agents
Daptomycin