Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative

Yoshihide Hattori; Hitoshi Yamamoto; Hideya Ando; Hirofumi Kondoh; Tomoyuki Asano; Mitsunori Kirihata; Yoshihiro Yamaguchi; Tateaki Wakamiya

doi:10.1016/j.bmc.2006.12.043

Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative

Bioorg Med Chem. 2007 Mar 1;15(5):2198-205. doi: 10.1016/j.bmc.2006.12.043. Epub 2007 Jan 10.

Authors

Yoshihide Hattori¹, Hitoshi Yamamoto, Hideya Ando, Hirofumi Kondoh, Tomoyuki Asano, Mitsunori Kirihata, Yoshihiro Yamaguchi, Tateaki Wakamiya

Affiliation

¹ Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.

PMID: 17241787
DOI: 10.1016/j.bmc.2006.12.043

Abstract

Boron-neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical tools for BNCT and MRI, novel compounds containing both the trifluoromethyl group and 10B atom in a single molecule were designed. In the present study, p-boronophenylalanine and p-boronophenylalaninol with the trifluoromethyl group were synthesized, and 19F NMR measurements of these compounds were carried out.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemistry*
Boron Compounds / chemical synthesis*
Boron Compounds / pharmacology*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Molecular Probes*
Phenylalanine / analogs & derivatives*
Phenylalanine / chemical synthesis
Phenylalanine / pharmacology
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

Alcohols
Boron Compounds
Molecular Probes
Phenylalanine
4-boronophenylalanine