Abstract
There is growing evidence that a functional polymorphism in the serotonin transporter gene (5-HTTLPR) moderates the impact of negative life events (e.g., childhood abuse) on the development of depression. However, it is unclear whether the gene x environment interaction predicts suicide attempts specifically. In addition, previous studies have not examined different forms of childhood abuse separately. In the current study, we found that 5-HTTLPR genotype moderated the link between childhood physical and sexual, but not emotional, abuse and adult psychiatric inpatients' histories of suicide attempts.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alleles
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Child
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Child Abuse / psychology*
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Child Abuse, Sexual / psychology
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Child Abuse, Sexual / statistics & numerical data
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Comorbidity
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Female
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Gene Frequency
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Genotype*
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Humans
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Male
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Mental Disorders / epidemiology
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Mental Disorders / psychology
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Middle Aged
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Polymorphism, Genetic / genetics
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Risk Factors
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Serotonin Plasma Membrane Transport Proteins / genetics*
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Social Environment
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Suicide, Attempted / psychology*
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Suicide, Attempted / statistics & numerical data
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United States
Substances
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Serotonin Plasma Membrane Transport Proteins