Anaemia and renal function in heart failure due to idiopathic dilated cardiomyopathy

Eur J Heart Fail. 2007 Apr;9(4):384-90. doi: 10.1016/j.ejheart.2006.10.013. Epub 2007 Jan 23.

Abstract

Background: Anaemia and renal dysfunction are common in patients with heart failure (HF). Most studies involve western cohorts with ischaemic aetiology receiving treatment likely to impair renal function.

Aims: To investigate the frequency of anaemia and renal dysfunction and the relationship between the two within a cohort of 163 newly diagnosed Black African idiopathic cardiomyopathy patients prior to commencing HF treatments and compare those findings to those of western HF cohorts.

Methods: Single-centre retrospective analysis. Anaemia defined as haemoglobin concentration<13.0 g/dL for males (n=85) and <12 g/dL for females (n=78). Probable renal dysfunction defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m2, using serum creatinine concentrations.

Results: The mean age was 48+/-11 years, 52% were male. Overall, 13.5% of patients were anaemic and 11.8% had evidence of renal dysfunction, while 1.2% had both. Renal dysfunction was significantly more common in older patients (mean age 58+/-13 vs. 47+/-10 years: p<0.001).

Conclusion: The frequency of anaemia and renal dysfunction in this cohort was lower than that reported in western HF cohorts. These data infer a more limited relationship between HF, anaemia and renal dysfunction in patients without atherothrombotic disease; hence extrapolation of HF data from the western world to other populations should be interpreted cautiously.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia / etiology*
  • Australia
  • Black People*
  • Cardiomyopathy, Dilated / complications*
  • Cardiomyopathy, Dilated / diagnosis
  • Female
  • Heart Failure / complications*
  • Heart Failure / epidemiology
  • Humans
  • Kidney / physiopathology*
  • Kidney Diseases / epidemiology
  • Kidney Diseases / etiology*
  • Male
  • Middle Aged
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • South Africa / epidemiology
  • Stroke Volume