Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia

Leukemia. 2007 Mar;21(3):588-90. doi: 10.1038/sj.leu.2404542. Epub 2007 Jan 25.
No abstract available

Publication types

  • Letter
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Animals
  • Child
  • Chromosome Breakage
  • Chromosomes, Human, Pair 11 / genetics*
  • Chromosomes, Human, Pair 11 / ultrastructure
  • Chromosomes, Human, Pair 19 / genetics*
  • Chromosomes, Human, Pair 19 / ultrastructure
  • DNA, Neoplasm / genetics
  • Exons / genetics
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Introns / genetics
  • Leukemia / genetics*
  • Mice
  • Myeloid-Lymphoid Leukemia Protein / chemistry
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Neoplasm Proteins / genetics*
  • Nuclear Proteins / genetics*
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics*
  • RNA, Neoplasm / biosynthesis
  • RNA, Neoplasm / genetics*
  • Trans-Splicing / genetics*
  • Transcription Factors / genetics*
  • Transcription, Genetic*
  • Translocation, Genetic / genetics*

Substances

  • DNA, Neoplasm
  • KMT2A protein, human
  • MLLT1 protein, human
  • Neoplasm Proteins
  • Nuclear Proteins
  • RNA, Messenger
  • RNA, Neoplasm
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase