Abstract
The aim of this study was to evaluate the cytotoxic effects of three new butanolides, subamolides A - C (1-3), and a new secobutanolide, secosubamolide (4), on the human colorectal cancer cell line SW480. Compounds 1-4 are new and were isolated from the stems of Cinnamomum subavenium, along with 17 known compounds. The structures of 1-4 were determined by spectroscopic analysis. Propidium iodide staining and flow cytometry were used to evaluate DNA damage of the treated SW480 cells, and it was found that 1-4 caused DNA damage in a dose-dependent manner after 24 h of treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone* / analogs & derivatives
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4-Butyrolactone* / chemistry
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4-Butyrolactone* / isolation & purification
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4-Butyrolactone* / pharmacology
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Cinnamomum / chemistry*
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DNA Damage / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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subamolide A
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subamolide B
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subamolide C
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4-Butyrolactone