E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp

A Norrie Pearce; Elizabeth W Chia; Michael V Berridge; Elizabeth W Maas; Michael J Page; Victoria L Webb; Jacquie L Harper; Brent R Copp

doi:10.1021/np060188l

E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp

J Nat Prod. 2007 Jan;70(1):111-3. doi: 10.1021/np060188l.

Authors

A Norrie Pearce¹, Elizabeth W Chia, Michael V Berridge, Elizabeth W Maas, Michael J Page, Victoria L Webb, Jacquie L Harper, Brent R Copp

Affiliation

¹ TerraMarine Pharmaceuticals, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

PMID: 17253860
DOI: 10.1021/np060188l

Abstract

Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic methods as a new member of the rubrolide family, rubrolide O (1), existing as a mixture of E/Z isomers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents* / chemistry
Anti-Inflammatory Agents* / isolation & purification
Anti-Inflammatory Agents* / pharmacology
Furans* / chemistry
Furans* / isolation & purification
Furans* / pharmacology
Humans
Hydrocarbons, Halogenated* / chemistry
Hydrocarbons, Halogenated* / isolation & purification
Hydrocarbons, Halogenated* / pharmacology
Molecular Structure
Neutrophils / metabolism
New Zealand
Stereoisomerism
Urochordata / chemistry*

Substances

Anti-Inflammatory Agents
Furans
Hydrocarbons, Halogenated
rubrolide O