Abstract
In Medellin, Colombia, three Pseudomonas aeruginosa isolates with high-level carbapenem resistance (MIC>or=256 microg/ml) and an isolate of Citrobacter freundii with reduced susceptibility to imipenem produced the plasmid-mediated class A carbapenemase KPC-2. This is the first report of a KPC-type beta-lactamase identified outside of the family Enterobacteriaceae.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbapenems / metabolism
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Carbapenems / pharmacology
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Drug Resistance, Bacterial / genetics*
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Hydrolysis
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / enzymology*
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Pseudomonas aeruginosa / genetics
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Carbapenems
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beta-lactamase KPC-1
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beta-Lactamases